Opportunity Information: Apply for RFA NS 22 061
The Training Award to Promote Cross-Training in the Fields of Traumatic Brain Injury (TBI) as a Risk Factor for Alzheimers Disease/Alzheimers Disease Related Dementias (AD/ADRD) is a National Institutes of Health (NIH) funding opportunity from the U.S. Department of Health and Human Services designed to help established researchers broaden their expertise through structured, mentored training. The program uses the K18 career enhancement award mechanism and is specifically focused on strengthening the science that connects traumatic brain injury to later-life risk for Alzheimers disease and related dementias. The central goal is to accelerate progress by encouraging experienced investigators to step outside their primary discipline long enough to gain new skills, new conceptual frameworks, and new collaborative relationships that can reshape or expand their future research directions.
This opportunity targets cross-training in two directions, reflecting a deliberate effort to bridge communities that often work in parallel. One group of applicants consists of established TBI investigators who want to train with senior dementia researchers to deepen their understanding of AD/ADRD biology, clinical phenotypes, biomarkers, and research approaches commonly used in dementia studies. The second group consists of established dementia researchers who want to train with senior TBI investigators to build stronger grounding in TBI mechanisms, injury characterization, acute and chronic sequelae, and research methods unique to brain injury science. In both cases, the intent is not a typical early-career mentored pathway, but a short, focused period of career enhancement for investigators who already have independent research experience and want to pivot, extend, or integrate their work into this intersectional area.
The award is structured as a short-term mentored experience lasting up to two years. The emphasis is on acquiring new knowledge and skills that are directly relevant to understanding TBI as a risk factor for AD/ADRD, and on positioning the awardee to launch sustained, competitive research programs that integrate both fields after the training period ends. While specific training activities can vary depending on the applicant and mentor pairing, the spirit of the mechanism is hands-on immersion: learning new methodologies, adopting new analytic approaches, engaging with different patient populations or datasets, and gaining fluency in the literature and conceptual models of the partner field. Because it is a mentored career enhancement award, the mentor relationship and the training plan are core components, and the application is expected to make a clear case that the proposed cross-training fills concrete gaps in the candidate's expertise and will materially change what they can do scientifically.
The announcement is labeled "Clinical Trial Not Allowed," meaning applications should not propose an independent clinical trial as the primary project under this award. In practical terms, the work supported should be oriented toward career development and research skill acquisition rather than running a clinical trial as the main aim. Applicants typically need to ensure that any human subjects involvement is consistent with the FOA restrictions and that the project remains focused on training and research development within allowable boundaries.
In terms of administrative and eligibility context, the opportunity is a discretionary grant with a health focus and is associated with CFDA numbers 93.853 and 93.866. A wide range of organizations are listed as eligible applicants, including various levels of government, public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, tribal governments and tribal organizations, and certain housing authorities, with the note that additional eligibility clarifications may appear in the full announcement text. The opportunity number is RFA-NS-22-061, it was created on August 16, 2022, and the original closing date was November 4, 2022. NIH anticipated making around five awards, and the listing shows an award ceiling of 0, which generally indicates that a specific cap was not stated in that summary field and that applicants should rely on the full FOA for budget guidance and constraints.
Overall, this program is best understood as a catalyst for cross-pollination between TBI and dementia research. NIH is using a time-limited, mentored structure to encourage mid-career or established investigators to add missing competencies, build durable collaborations, and generate the foundation needed for future larger-scale projects that clarify how TBI contributes to the development or acceleration of AD/ADRD. The intended outcome is a stronger, more integrated research workforce capable of tackling mechanistic questions, improving risk characterization, and ultimately informing prevention and intervention strategies at the intersection of brain injury and neurodegeneration.Apply for RFA NS 22 061
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Training Award to Promote Cross-Training in the Fields of Traumatic Brain Injury (TBI) as a Risk Factor for Alzheimers Disease/Alzheimers Disease Related Dementias (AD/ADRD) (K18 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853, 93.866.
- This funding opportunity was created on Aug 16, 2022.
- Applicants must submit their applications by Nov 04, 2022. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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