Opportunity Information: Apply for RFA NS 22 061
The Training Award to Promote Cross-Training in the Fields of Traumatic Brain Injury (TBI) as a Risk Factor for Alzheimers Disease/Alzheimers Disease Related Dementias (AD/ADRD) is a National Institutes of Health (NIH) funding opportunity from the U.S. Department of Health and Human Services designed to help established researchers broaden their expertise through structured, mentored training. The program uses the K18 career enhancement award mechanism and is specifically focused on strengthening the science that connects traumatic brain injury to later-life risk for Alzheimers disease and related dementias. The central goal is to accelerate progress by encouraging experienced investigators to step outside their primary discipline long enough to gain new skills, new conceptual frameworks, and new collaborative relationships that can reshape or expand their future research directions.
This opportunity targets cross-training in two directions, reflecting a deliberate effort to bridge communities that often work in parallel. One group of applicants consists of established TBI investigators who want to train with senior dementia researchers to deepen their understanding of AD/ADRD biology, clinical phenotypes, biomarkers, and research approaches commonly used in dementia studies. The second group consists of established dementia researchers who want to train with senior TBI investigators to build stronger grounding in TBI mechanisms, injury characterization, acute and chronic sequelae, and research methods unique to brain injury science. In both cases, the intent is not a typical early-career mentored pathway, but a short, focused period of career enhancement for investigators who already have independent research experience and want to pivot, extend, or integrate their work into this intersectional area.
The award is structured as a short-term mentored experience lasting up to two years. The emphasis is on acquiring new knowledge and skills that are directly relevant to understanding TBI as a risk factor for AD/ADRD, and on positioning the awardee to launch sustained, competitive research programs that integrate both fields after the training period ends. While specific training activities can vary depending on the applicant and mentor pairing, the spirit of the mechanism is hands-on immersion: learning new methodologies, adopting new analytic approaches, engaging with different patient populations or datasets, and gaining fluency in the literature and conceptual models of the partner field. Because it is a mentored career enhancement award, the mentor relationship and the training plan are core components, and the application is expected to make a clear case that the proposed cross-training fills concrete gaps in the candidate's expertise and will materially change what they can do scientifically.
The announcement is labeled "Clinical Trial Not Allowed," meaning applications should not propose an independent clinical trial as the primary project under this award. In practical terms, the work supported should be oriented toward career development and research skill acquisition rather than running a clinical trial as the main aim. Applicants typically need to ensure that any human subjects involvement is consistent with the FOA restrictions and that the project remains focused on training and research development within allowable boundaries.
In terms of administrative and eligibility context, the opportunity is a discretionary grant with a health focus and is associated with CFDA numbers 93.853 and 93.866. A wide range of organizations are listed as eligible applicants, including various levels of government, public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, tribal governments and tribal organizations, and certain housing authorities, with the note that additional eligibility clarifications may appear in the full announcement text. The opportunity number is RFA-NS-22-061, it was created on August 16, 2022, and the original closing date was November 4, 2022. NIH anticipated making around five awards, and the listing shows an award ceiling of 0, which generally indicates that a specific cap was not stated in that summary field and that applicants should rely on the full FOA for budget guidance and constraints.
Overall, this program is best understood as a catalyst for cross-pollination between TBI and dementia research. NIH is using a time-limited, mentored structure to encourage mid-career or established investigators to add missing competencies, build durable collaborations, and generate the foundation needed for future larger-scale projects that clarify how TBI contributes to the development or acceleration of AD/ADRD. The intended outcome is a stronger, more integrated research workforce capable of tackling mechanistic questions, improving risk characterization, and ultimately informing prevention and intervention strategies at the intersection of brain injury and neurodegeneration.Apply for RFA NS 22 061
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Training Award to Promote Cross-Training in the Fields of Traumatic Brain Injury (TBI) as a Risk Factor for Alzheimers Disease/Alzheimers Disease Related Dementias (AD/ADRD) (K18 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853, 93.866.
- This funding opportunity was created on Aug 16, 2022.
- Applicants must submit their applications by Nov 04, 2022. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Frequently Asked Questions (FAQs)
What is this funding opportunity?
This opportunity is the NIH Training Award to Promote Cross-Training in the Fields of Traumatic Brain Injury (TBI) as a Risk Factor for Alzheimers Disease/Alzheimers Disease Related Dementias (AD/ADRD). It is a U.S. Department of Health and Human Services discretionary grant designed to help established researchers broaden their expertise through structured, mentored training.
What is the official opportunity number?
The opportunity number is RFA-NS-22-061.
Which NIH award mechanism does this program use?
The program uses the K18 career enhancement award mechanism, which is intended for a time-limited, mentored period of career development and skill acquisition for investigators who already have independent research experience.
What is the main goal of the award?
The central goal is to strengthen the science connecting traumatic brain injury to later-life risk for Alzheimers disease and related dementias by enabling experienced investigators to gain new skills, conceptual frameworks, and collaborations that can reshape or expand their future research direction.
Who is this award intended for?
It is intended for established investigators (not a typical early-career mentored pathway) who want a short, focused period of career enhancement to pivot, extend, or integrate their research into the intersection of TBI and AD/ADRD.
What kinds of cross-training pathways does the program support?
The program supports cross-training in two directions: (1) established TBI investigators training with senior dementia researchers to deepen expertise in AD/ADRD, and (2) established dementia researchers training with senior TBI investigators to strengthen grounding in TBI science and methods.
What topics might a TBI investigator seek training in on the dementia side?
Examples described include AD/ADRD biology, clinical phenotypes, biomarkers, and research approaches commonly used in dementia studies.
What topics might a dementia investigator seek training in on the TBI side?
Examples described include TBI mechanisms, injury characterization, acute and chronic sequelae, and research methods unique to brain injury science.
How long can the mentored training period last?
The award supports a short-term mentored experience lasting up to two years.
What is the emphasis of the supported work?
The emphasis is on acquiring new knowledge and skills directly relevant to understanding TBI as a risk factor for AD/ADRD, and on positioning the awardee to launch sustained, competitive research programs that integrate both fields after the training period.
What kinds of training activities fit the spirit of this program?
The description emphasizes hands-on immersion such as learning new methodologies, adopting new analytic approaches, engaging with different patient populations or datasets, and gaining fluency in the literature and conceptual models of the partner field.
Why is the mentor relationship important for this award?
Because this is a mentored career enhancement award, the mentor relationship and the training plan are core components. The application is expected to clearly explain how the proposed cross-training fills specific gaps in the candidate's expertise and will materially change what the candidate can do scientifically.
Are clinical trials allowed under this opportunity?
No. The announcement is labeled "Clinical Trial Not Allowed," meaning the application should not propose an independent clinical trial as the primary project under this award.
If clinical trials are not allowed, what does NIH expect instead?
The supported work should be oriented toward career development and research skill acquisition rather than running a clinical trial as the main aim, while ensuring any human subjects involvement remains consistent with the FOA restrictions and the project stays focused on training and research development within allowable boundaries.
What types of organizations are eligible to apply?
The listing describes a broad set of eligible applicants, including various levels of government, public and private institutions of higher education, nonprofit organizations (with and without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, tribal governments and tribal organizations, and certain housing authorities. Additional eligibility clarifications may appear in the full announcement text.
Which CFDA numbers are associated with this opportunity?
The opportunity is associated with CFDA numbers 93.853 and 93.866.
When was this opportunity created and when did it close?
The listing states it was created on August 16, 2022, and the original closing date was November 4, 2022.
How many awards did NIH expect to make?
NIH anticipated making around five awards.
Is there a stated maximum award amount (ceiling)?
The listing shows an award ceiling of 0, which generally indicates that a specific cap was not stated in that summary field and that applicants should rely on the full FOA for budget guidance and constraints.
What is the intended long-term outcome of the program?
The intended outcome is a stronger, more integrated research workforce capable of tackling mechanistic questions, improving risk characterization, and informing prevention and intervention strategies at the intersection of brain injury and neurodegeneration.
How should applicants frame the value of the cross-training?
Based on the description, applicants should make a clear case that the training addresses concrete gaps in their expertise, provides skills and conceptual tools not available in their primary discipline, and creates collaborations that will continue to shape and strengthen their research after the award period.
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