Opportunity Information: Apply for CDC RFA GH21 2127
This funding opportunity (CDC RFA GH21-2127) is a PEPFAR-supported cooperative agreement from the U.S. Department of Health and Human Services, Centers for Disease Control and Prevention (CDC), aimed at strengthening HIV prevention, care, and treatment services for key populations in South Africa. The program is structured as a multi-year effort, planned over five years, and is designed to support targeted, comprehensive service delivery for groups that face disproportionately high HIV risk and significant barriers to accessing health services. The key populations specifically named are sex workers (SWs), men who have sex with men (MSM), transgender people (TG), and people who inject drugs (PWID). The overall emphasis is on practical, on-the-ground service delivery that combines HIV prevention, testing, and treatment with integrated care for common co-infections and related conditions.
For funding, the notice states that the Year 1 award ceiling is listed as 0 (meaning there is no fixed upper limit specified per award for that first year), while CDC anticipates approximately $11,000,000 total available in Fiscal Year 1, contingent on the availability of funds. The opportunity anticipates making around three awards. Because this is a cooperative agreement, recipients should expect substantial CDC involvement in planning, implementation support, monitoring, and alignment with PEPFAR priorities, rather than a hands-off grant model. Eligibility is described as unrestricted, meaning a wide range of organizations can apply, subject to any additional eligibility clarifications included in the full announcement.
Programmatically, the NOFO calls for a comprehensive and targeted package of services that spans the HIV prevention-to-treatment continuum. That includes prevention interventions, HIV testing or screening, rapid linkage to care, and sustained antiretroviral treatment support. It also explicitly requires attention to related diseases and co-morbidities that commonly intersect with HIV risk and outcomes, including tuberculosis (TB), sexually transmitted infections (STIs), and viral hepatitis. In practice, the intent is to avoid siloed services and instead provide integrated, client-centered care that meets key populations where they are, reduces drop-off between steps (testing to treatment, treatment to viral suppression), and addresses the clinical realities of co-infection and syndemics.
In addition to core HIV and related-disease services, the NOFO highlights complementary services that should be included as needed based on client circumstances. Examples named include sexual and reproductive health services and opioid substitution therapy (OST), which is particularly relevant for PWID programming and harm reduction approaches. This framing signals that CDC and PEPFAR are looking for implementers that can deliver a complete package rather than isolated activities, with service models capable of addressing structural and behavioral drivers of risk, supporting retention in care, and improving health outcomes in stigmatized and often hard-to-reach communities.
Geographically, the opportunity specifies distinct district footprints for each key population-focused program. The sex worker program is expected to operate in 5 to 9 districts, specifically including eThekwini and uMgungundlovu in KwaZulu-Natal; OR Tambo in the Eastern Cape; Dr. Kenneth Kaunda and Ngaka Modiri Molema in North West; and Nkangala, Gert Sibande, and Ehlanzeni in Mpumalanga. The MSM and transgender program is planned for five districts: eThekwini and uMgungundlovu in KwaZulu-Natal; Tshwane and Ekurhuleni in Gauteng; and Ehlanzeni in Mpumalanga. The PWID program is more geographically concentrated, operating in two districts: Tshwane in Gauteng and Ehlanzeni in Mpumalanga. The notice also leaves room for later geographic expansion, depending on changing epidemic needs and PEPFAR prioritization, which indicates the program is intended to remain adaptable as data and policy direction evolve.
Key administrative details include the opportunity category (discretionary), activity category (health), and CFDA number 93.067. The original posting date is January 11, 2021, with an original application deadline of March 12, 2021, and an electronic submission cutoff of 11:59 p.m. Eastern Time on the due date. Overall, the NOFO is centered on scaling effective, evidence-informed HIV service delivery for key populations in specified high-priority districts, with integrated clinical and supportive services intended to improve prevention coverage, case finding, linkage, treatment continuity, and outcomes such as viral suppression, while also addressing TB, STIs, and viral hepatitis in a coordinated way.Apply for CDC RFA GH21 2127
- The Department of Health and Human Services, Centers for Disease Control - CGH in the health sector is offering a public funding opportunity titled "Provide Comprehensive Packages of HIV Prevention, Care, and Treatment Services for Key Populations in South Africa under the President's Emergency Plan for AIDS Relief (PEPFAR)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.067.
- This funding opportunity was created on Jan 11, 2021.
- Applicants must submit their applications by Mar 12, 2021 Electronically submitted applications must be submitted no later than 1159 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Browse more opportunities from the same category: Health
Next opportunity: U.S. Ambassador's Special Self Help Fund
Previous opportunity: DoD Breast Cancer, Breakthrough Award Level 4
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for CDC RFA GH21 2127
Applicants also applied for:
Applicants who have applied for this opportunity (CDC RFA GH21 2127) also looked into and applied for these:
| Funding Opportunity |
|---|
| Rural Communities Opioid Response Program-Psychostimulant Support Apply for HRSA 21 091 Funding Number: HRSA 21 091 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: $500,000 |
| Strengthen Capacity of South African Government's Department of Health and Implementing Partners to Deliver Quality Differentiated, Advanced Clinical Care (ACC) for Unstable HIV and TB/HIV Patients in the Republic of South Africa (SA) under PEPF Apply for CDC RFA GH21 2122 Funding Number: CDC RFA GH21 2122 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Supporting Laboratory Systems Strengthening Activities in Zimbabwe under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH21 2145 Funding Number: CDC RFA GH21 2145 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Improving Mental Health and HIV/TB Service Integration (IMHSI) in South Africa under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH21 2124 Funding Number: CDC RFA GH21 2124 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Human Papillomavirus (HPV) Roundtable: Supporting a National Network of Partners to Promote Cancer Prevention through Human Papillomavirus Vaccination Apply for CDC RFA IP21 2105 Funding Number: CDC RFA IP21 2105 Agency: Department of Health and Human Services, Centers for Disease Control - NCIRD Category: Health Funding Amount: Case Dependent |
| Evidence Based Telehealth Network Program Apply for HRSA 21 082 Funding Number: HRSA 21 082 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: $350,000 |
| Behavioral Health Workforce Education and Training (BHWET) Program for Paraprofessionals Apply for HRSA 21 090 Funding Number: HRSA 21 090 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Autism Secondary Data Analysis Research Program Apply for HRSA 21 052 Funding Number: HRSA 21 052 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Sustainable National Health Laboratory Systems and Partnerships in Uganda under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH21 2140 Funding Number: CDC RFA GH21 2140 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Prevention and Control of Infections/Epidemics/Pandemics of Patients at Risk or Infected with HIV and/or TB/HIV in South Africa under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH21 2125 Funding Number: CDC RFA GH21 2125 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Improving Epilepsy Education, Systems of Care, and Health Outcomes through National and Community Partnerships Apply for CDC RFA DP21 2101 Funding Number: CDC RFA DP21 2101 Agency: Department of Health and Human Services, Centers for Disease Control - NCCDPHP Category: Health Funding Amount: $4,400,000 |
| Rigorous Evaluation of Policies for their Impacts on the Primary Prevention of Multiple Forms of Violence Apply for RFA CE 21 001 Funding Number: RFA CE 21 001 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $350,000 |
| INTUIT-PC: Improving Nonsurgical Treatment of Urinary Incontinence among women in Primary Care: Dissemination and Implementation of PCOR Evidence (U18) Apply for RFA HS 21 001 Funding Number: RFA HS 21 001 Agency: Department of Health and Human Services, Agency for Health Care Research and Quality Category: Health Funding Amount: $2,000,000 |
| Strengthening Epidemiology and Strategic Information in the Republic of Zimbabwe under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH21 2146 Funding Number: CDC RFA GH21 2146 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Strengthening the Government of Tanzania's Capacity to Develop, Implement and Use Digital Health to Achieve HIV/TB Epidemic Control through Interoperable Information Systems, Governance, Quality Improvement and Workforce Support under PEPFAR Apply for CDC RFA GH21 2136 Funding Number: CDC RFA GH21 2136 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Scaling Up Comprehensive Facility and Community HIV Prevention, Care and Treatment Programs for Key and Vulnerable Populations, and People Living with HIV (PLHIV) in Tanzania under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH21 2135 Funding Number: CDC RFA GH21 2135 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Advancing Arthritis Public Health Priorities through National Organizations Apply for CDC RFA DP21 2106 Funding Number: CDC RFA DP21 2106 Agency: Department of Health and Human Services, Centers for Disease Control - NCCDPHP Category: Health Funding Amount: $1,000,000 |
| Vision Screening in Young Children Program Apply for HRSA 21 033 Funding Number: HRSA 21 033 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: $300,000 |
| HIV/TB Agency, Information, and Services Activity (HIV/TB AIS) Apply for 72048221RFA00001 Funding Number: 72048221RFA00001 Agency: Agency for International Development, Burma USAID - Rangoon Category: Health Funding Amount: $39,000,000 |
| USAID Improved Family Planning Initiative Apply for 72065621RFA00001 IFPI Funding Number: 72065621RFA00001 IFPI Agency: Agency for International Development, Mozambique USAID-Maputo Category: Health Funding Amount: $39,900,011 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "CDC RFA GH21 2127", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.