Opportunity Information: Apply for PAR 21 220
The NIA Advanced Postdoctoral Career Transition Awards to Promote Diversity in Translational Research for AD/ADRD (K99/R00, Clinical Trial Not Allowed) is a National Institutes of Health grant opportunity designed to strengthen and diversify the pipeline of scientists who can translate Alzheimer s disease and Alzheimer s disease-related dementias (AD/ADRD) research into practical advances. The program is built around the idea that progress in prevention, early detection, diagnosis, treatment development, and care strategies depends on a workforce that is both scientifically versatile and broadly representative of diverse backgrounds and perspectives. This award specifically supports early-career investigators at the advanced postdoctoral stage who are preparing to become independent faculty-level researchers, with an emphasis on helping them acquire translational skills that are often difficult to gain in a standard postdoctoral path.
A central focus of the award is targeted training and career development in data science and drug discovery, and the application of those skills across the full range of AD/ADRD research areas. That scope is intentionally broad: projects may span population and cohort studies, biomarker and diagnostics development, mechanistic and preclinical work that informs new interventions, and behavioral and social research that improves outcomes for individuals, families, and communities. The expectation is that awardees will become the kind of scientists who can move between disciplines, work effectively in team-science environments, and contribute to precision medicine approaches for AD/ADRD, whether by leading collaborative efforts or serving as key translational experts within larger research teams.
As a K99/R00 career transition mechanism, the structure is meant to support a two-step progression: an initial mentored phase (K99) that strengthens technical and translational expertise and positions the candidate for independence, followed by an independent phase (R00) that supports the launch of an autonomous research program once the individual secures a suitable independent research position. While the detailed budgets and timelines are not provided in the text you shared, the overall purpose is clear: help promising postdoctoral researchers from diverse backgrounds bridge the gap between mentored training and independent, impactful translational research careers in AD/ADRD.
Eligibility for applicant organizations is broad, reflecting NIH s intent to reach many different types of research and community settings. Eligible applicants include public and private institutions of higher education, state and local governments, independent school districts, special district governments, federally recognized Native American tribal governments, tribal organizations that are not federally recognized, public housing authorities and Indian housing authorities, nonprofit organizations (both with and without 501(c)(3) status), for-profit organizations (other than small businesses), and small businesses. The announcement also highlights additional eligible applicant categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and certain eligible federal agencies. Foreign organizations may apply as non-domestic entities, and foreign components (as NIH defines them) are allowed; however, non-U.S. components of U.S. organizations are explicitly not eligible to apply.
Administratively, this is a discretionary NIH grant in the health funding category, listed under CFDA 93.866, and the funding opportunity number is PAR-21-220. The original closing date shown in the source data is July 12, 2024, and the award ceiling and expected number of awards are not specified in the information provided. The key practical constraint embedded in the title is that clinical trials are not allowed under this FOA, meaning applicants need to design research and career development plans that fit NIH s definition of non-clinical-trial activities while still advancing translational goals in AD/ADRD.
Overall, the award is best understood as a workforce and career development investment aimed at increasing both the diversity and the translational readiness of the next generation of independent AD/ADRD investigators. By concentrating on data science and drug discovery skills, and by encouraging application of those tools across biomedical, behavioral, and social dimensions of dementia research, the program aims to produce researchers who can help drive real-world advances in treatment, prevention, early detection, and care.Apply for PAR 21 220
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NIA Advanced Postdoctoral Career Transition Awards to Promote Diversity in Translational Research for AD/ADRD (K99/R00 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
- This funding opportunity was created on 2021-05-28.
- Applicants must submit their applications by 2024-07-12. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: NIA Advanced Postdoctoral Career Transition Awards to Promote Diversity in Translational Research for AD/ADRD (K99/R00, Clinical Trial Not Allowed) - PAR-21-220
What is this funding opportunity?
This opportunity is the NIA Advanced Postdoctoral Career Transition Awards to Promote Diversity in Translational Research for Alzheimer s disease and Alzheimer s disease-related dementias (AD/ADRD). It uses the NIH K99/R00 career transition mechanism and is designed to help advanced postdoctoral researchers move from mentored training into independent, faculty-level research careers focused on translational AD/ADRD work.
What is the main goal of the award?
The goal is to strengthen and diversify the workforce of scientists who can translate AD/ADRD research into practical advances. The program emphasizes building a pipeline of researchers who can contribute to prevention, early detection, diagnosis, treatment development, and care strategies, while also supporting a workforce that is broadly representative of diverse backgrounds and perspectives.
Who is this award intended for?
It is intended for early-career investigators at the advanced postdoctoral stage who are preparing to become independent researchers. The award is specifically positioned for people who are close to making the transition from postdoctoral training to an independent research role.
How does the K99/R00 structure work in this program?
The award supports a two-step progression. The first step is the mentored K99 phase, focused on career development and gaining technical and translational expertise. The second step is the independent R00 phase, which supports launching an autonomous research program after the awardee secures an independent research position.
What kinds of training and skills does this award emphasize?
A central focus is targeted training and career development in data science and drug discovery, and applying those skills across a broad range of AD/ADRD research areas. The intent is to help candidates build translational capabilities that are often hard to acquire during a typical postdoctoral path.
What research areas are within scope for this FOA?
The scope is intentionally broad across AD/ADRD translational research. Examples mentioned include population and cohort studies, biomarker and diagnostics development, mechanistic and preclinical work that informs new interventions, and behavioral and social research aimed at improving outcomes for individuals, families, and communities.
Does the program expect applicants to work across disciplines?
Yes. The program emphasizes developing scientists who can move between disciplines, operate effectively in team-science environments, and contribute to precision medicine approaches in AD/ADRD. Applicants are expected to be able to lead collaborative efforts or serve as key translational experts on larger teams.
Are clinical trials allowed under this funding opportunity?
No. The FOA title states Clinical Trial Not Allowed. Applicants should design research and career development plans that fit NIH definitions of non-clinical-trial activities while still advancing translational objectives in AD/ADRD.
Which NIH Institute is associated with this award?
The opportunity is associated with the National Institute on Aging (NIA), part of the National Institutes of Health (NIH).
What is the funding opportunity number and CFDA listing?
The funding opportunity number is PAR-21-220. The listing provided is CFDA 93.866.
What type of grant is this categorized as?
It is described as a discretionary NIH grant in the health funding category and uses the K99/R00 career transition mechanism.
What is meant by translational research in the context of this award?
Based on the description provided, translational research here means work that helps move AD/ADRD science toward practical advances in prevention, early detection, diagnosis, treatment development, and care strategies. The FOA highlights developing capabilities that connect discovery and applied outcomes, including through data science and drug discovery training.
What kinds of organizations are eligible to apply?
Eligibility for applicant organizations is broad. The provided list includes public and private institutions of higher education; state and local governments; independent school districts; special district governments; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities and Indian housing authorities; nonprofit organizations (with or without 501(c)(3) status); for-profit organizations (other than small businesses); and small businesses.
Are minority-serving institutions and community-based organizations included as eligible applicants?
Yes. The announcement highlights additional eligible applicant categories including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). It also notes faith-based or community-based organizations and regional organizations.
Are U.S. territories or possessions eligible to apply?
Yes. U.S. territories or possessions are listed among the additional eligible applicant categories.
Can foreign organizations apply?
Yes. Foreign organizations may apply as non-domestic entities, and foreign components (as NIH defines them) are allowed.
Are non-U.S. components of U.S. organizations eligible to apply?
No. The information provided states that non-U.S. components of U.S. organizations are explicitly not eligible to apply.
Is the award focused only on biomedical lab research?
No. The scope described includes biomedical, behavioral, and social dimensions of dementia research. In addition to mechanistic and preclinical work, the FOA explicitly includes behavioral and social research that improves outcomes for individuals, families, and communities.
Does the opportunity specify the award ceiling or expected number of awards?
No. The award ceiling and the expected number of awards are not specified in the information provided.
Does the opportunity provide detailed budgets and timelines?
No. The description notes that detailed budgets and timelines are not provided in the information shared, while emphasizing the overall K99 mentored phase followed by the R00 independent phase.
What is the closing date shown in the source data?
The original closing date shown is July 12, 2024.
What is the program trying to produce in terms of career outcomes?
The program aims to help promising advanced postdoctoral researchers become independent AD/ADRD investigators with strong translational readiness. The intended outcome is a new generation of scientists capable of driving real-world advances in treatment, prevention, early detection, and care by leveraging data science and drug discovery skills across diverse AD/ADRD research areas.
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Previous opportunity: Mentored Career Development Award to Promote Faculty Diversity in Biomedical Research (K01 Independent Clinical Trial Not Allowed)
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| Funding Opportunity |
|---|
| NIA Predoctoral Fellowship Award to Promote Diversity in Translational Research for AD/ADRD (F31) Apply for PAR 21 218 Funding Number: PAR 21 218 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD), Diagnostic-Telemedicine Resource (U24 Clinical Trial Not Allowed) Apply for RFA AA 21 012 Funding Number: RFA AA 21 012 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD), Developmental Project (UH2 Clinical Trial Optional) Apply for RFA AA 21 014 Funding Number: RFA AA 21 014 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD), Data Coordination Resource (U24 Clinical Trial Not Allowed) Apply for RFA AA 21 013 Funding Number: RFA AA 21 013 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD), Administrative Resource (U24) (Clinical Trial Not Allowed) Apply for RFA AA 21 011 Funding Number: RFA AA 21 011 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD), Research Project (U01 Clinical Trial optional) Apply for RFA AA 21 010 Funding Number: RFA AA 21 010 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Non-Human Primate Developmental Genotype-Tissue Expression (NHP dGTEx) Project (U24 Clinical Trials Not Allowed) Apply for RFA HG 21 026 Funding Number: RFA HG 21 026 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIH Directors Transformative Research Awards (R01 Clinical Trial Optional) Apply for RFA RM 21 017 Funding Number: RFA RM 21 017 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Shared Personal Protective Equipment (PPE) Resources (S10 Clinical Trial Not Allowed) Apply for PAR 21 257 Funding Number: PAR 21 257 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Integration, Dissemination, and Evaluation (BRIDGE) Center for the NIH Bridge to Artificial Intelligence (Bridge2AI) Program (U54 Clinical Trial Not Allowed) Apply for RFA RM 21 023 Funding Number: RFA RM 21 023 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Large Research Projects for Prevention of Healthcare-Associated Infections (R01) Apply for PA 21 265 Funding Number: PA 21 265 Agency: Agency for Health Care Research and Quality Category: Health Funding Amount: $500,000 |
| High Resolution Mapping of Biomolecules in Brain Cells in Aging and Alzheimers Disease (R01 Clinical Trial Not Allowed) Apply for RFA AG 22 019 Funding Number: RFA AG 22 019 Agency: National Institutes of Health Category: Health Funding Amount: $500,000 |
| Promoting Bunyavirales Basic Science Research (R01 Clinical Trial Not Allowed) Apply for RFA AI 21 046 Funding Number: RFA AI 21 046 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIA Research and Entrepreneurial Development Immersion (REDI): Entrepreneurial Small Business Transition Award (R41/R42 Clinical Trial Optional) Apply for RFA AG 22 014 Funding Number: RFA AG 22 014 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIA Research and Entrepreneurial Development Immersion (REDI): Mentored Entrepreneurial Career Development Award (K01 Clinical Trial Not Allowed) Apply for RFA AG 22 004 Funding Number: RFA AG 22 004 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIA Research and Entrepreneurial Development Immersion (REDI): Entrepreneurial Small Business Transition Award (R43/R44 Clinical Trial Optional) Apply for RFA AG 22 007 Funding Number: RFA AG 22 007 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIA Research and Entrepreneurial Development Immersion (REDI): Entrepreneurship Enhancement Award (R25 Clinical Trial Not Allowed) Apply for RFA AG 22 003 Funding Number: RFA AG 22 003 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Feasibility Clinical Trials of Mind and Body Interventions for NCCIH High Priority Research Topics (R34 Clinical Trial Required) Apply for PAR 21 240 Funding Number: PAR 21 240 Agency: National Institutes of Health Category: Health Funding Amount: $225,000 |
| Clinical Coordinating Center for NCCIH Multi-Site Investigator-Initiated Clinical Trials of Mind and Body Interventions (Collaborative UG3/UH3 Clinical Trial Required) Apply for PAR 21 243 Funding Number: PAR 21 243 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Data Coordinating Center for NCCIH Multi-Site Investigator-Initiated Clinical Trials of Mind and Body Interventions (Collaborative U24 Clinical Trial Required) Apply for PAR 21 242 Funding Number: PAR 21 242 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
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