Opportunity Information: Apply for PA 25 212
The Innovation Corps (I-Corps) at NIH Program for NIH and CDC Translational Research (PA 25-212) is a discretionary grant opportunity from the National Institutes of Health that offers administrative supplement awards to certain active small business awardees. The central purpose of the program is to strengthen commercialization readiness for NIH- and CDC-funded translational technologies by training teams to test and validate a business model through structured, real-world customer discovery. A key restriction is that this opportunity is an administrative supplement mechanism and clinical trials are not allowed under this NOFO.
Eligibility is narrowly targeted to teams that already have active awards in the NIH/CDC small business programs. Specifically, the supplements are intended for active NIH and CDC SBIR awardees and active NIH STTR Phase I awardees. There is also an important timing flexibility: SBIR and STTR Phase I awardees who are in a no-cost extension can still be eligible, but only if the no-cost extension period would cover the entire duration of the selected I-Corps cohort. In practical terms, the underlying Phase I award must remain active for the full training window so the supplement can be administered appropriately. The funding announcement also makes clear that foreign participation is restricted: non-U.S. (foreign) organizations cannot apply, non-U.S. components of U.S. organizations are not eligible, and foreign components (as defined by the NIH Grants Policy Statement) are not allowed.
Programmatically, I-Corps at NIH is designed to move teams beyond a purely technical development mindset and into evidence-based commercialization planning. The mission is to empower entrepreneurs to develop and validate a strategic business model that addresses unmet clinical needs, using broad and diverse customer discovery. The expectation is that teams will engage with stakeholders such as potential users, purchasers, payers, clinical decision-makers, partners, and other market actors to test assumptions about the problem, the value proposition, adoption barriers, and routes to market. The intended result is not just a polished pitch, but a set of validated insights that can meaningfully change the direction of a product strategy when necessary.
The training structure is team-based and built around a three-member project team model. Those teams receive instruction and mentoring intended to accelerate translation of technologies already being developed with NIH and CDC SBIR/STTR support. While the notice emphasizes education and mentoring rather than additional R and D, the supplement is meant to help awardees systematically pressure-test their commercialization approach, clarify who the real customer is, refine the target use case, and understand what evidence (clinical, regulatory, reimbursement, workflow, or economic) will be needed to succeed.
NIH and CDC describe anticipated outcomes in very concrete commercialization terms. Teams that complete the cohort are expected to come out with significantly refined commercialization plans, along with better-grounded decisions about whether to pivot elements of their strategy. A "pivot" in this context can mean narrowing or changing the initial target market, adjusting the product concept to fit stakeholder needs, revising pricing and reimbursement assumptions, changing partnership strategy, or rethinking the pathway to regulatory clearance and adoption. The overall aim is to reduce commercialization risk by replacing internal assumptions with external validation gathered through disciplined customer discovery.
Prospective applicants are strongly encouraged to contact NIH scientific/research staff before applying, which signals that program fit and eligibility details matter and that early conversation can help confirm whether a given Phase I SBIR/STTR project aligns with the cohort expectations and administrative supplement requirements. Administrative details provided in the posting include the agency (NIH), the opportunity number (PA 25-212), the original closing date (2025-01-31), the grant instrument type (grant), and multiple CFDA listings associated with NIH program areas. The posting also lists eligible applicants as public and state-controlled institutions of higher education, but the narrative description makes clear that the operational target audience is active SBIR and eligible STTR Phase I grantees/awardees seeking an administrative supplement to participate in the I-Corps training cohort. For final determinations, applicants are directed to the funding announcement for full eligibility and application requirements.Apply for PA 25 212
- The National Institutes of Health in the education, environment, food and nutrition, health, income security and social services sector is offering a public funding opportunity titled "Innovation Corps (I-Corps) at NIH Program for NIH and CDC Translational Research (Admin Supp Clinical Trial NOT Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.083, 93.084, 93.113, 93.121, 93.143, 93.172, 93.173, 93.213, 93.233, 93.242, 93.262, 93.273, 93.279, 93.307, 93.350, 93.351, 93.394, 93.395, 93.837, 93.838, 93.839, 93.840, 93.846, 93.847, 93.853, 93.855, 93.859, 93.865, 93.866, 93.867.
- This funding opportunity was created on 2024-10-28.
- Applicants must submit their applications by 2025-01-31. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Public and State controlled institutions of higher education.
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| Funding Opportunity |
|---|
| Dissemination and Implementation Research in Health (R01 Clinical Trial Optional) Apply for PAR 25 144 Funding Number: PAR 25 144 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Not Allowed) Apply for PAR 25 134 Funding Number: PAR 25 134 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $375,000 |
| NIH Research Project Grant (Parent R01 Clinical Trial Required) Apply for PA 25 305 Funding Number: PA 25 305 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed) Apply for PA 25 301 Funding Number: PA 25 301 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required) Apply for PA 25 303 Funding Number: PA 25 303 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Intervention Research to Improve Native American Health (R01 Clinical Trial Optional) Apply for PAR 25 379 Funding Number: PAR 25 379 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Support for Research Excellence (SuRE) Award (R16 Clinical Trial Not Allowed) Apply for PAR 25 414 Funding Number: PAR 25 414 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $100,000 |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions Without NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30) Apply for PA 25 425 Funding Number: PA 25 425 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (Parent F32) Apply for PA 25 423 Funding Number: PA 25 423 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions with NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30) Apply for PA 25 426 Funding Number: PA 25 426 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31) Apply for PA 25 422 Funding Number: PA 25 422 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Support for Research Excellence First Independent Research (SuRE-First) Award (R16 - Clinical Trial Not Allowed) Apply for PAR 25 415 Funding Number: PAR 25 415 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $125,000 |
| Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed) Apply for PAR 25 322 Funding Number: PAR 25 322 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
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